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schneekloth j rna drug target next frontier medicinal chemistry 2024

Type:: E-books
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Uploaded On:: July 30, 2024, 11:39 a.m.
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Textbook in PDF format Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs. Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete “toolbox” for working with RNA, from structure determination to screening and lead generation techniques. A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more. Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome. RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry. Introduction RNA Structure Probing, Dynamics, and Folding High-Resolution Structures of RNA Screening and Lead Generation Techniques for RNA Binders Chemical Matter That Binds RNA MicroRNAs as Targets for Small-Molecule Binders Pre-mRNA Splicing Modulation Prospects for Riboswitches in Drug Development Small Molecules That Degrade RNA Approaches to the Identification of Molecules Altering Programmed Ribosomal Frameshifting in Viruses RNA–Protein Interactions: A New Approach for Drugging RNA Biology Drugging the Epitranscriptome Outlook

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schneekloth j rna drug target next frontier medicinal chemistry 2024