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deepa p genetics nurses 2ed 2024

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Textbook in PDF format Foreword Preface About the Author Nature, Principles and Perspectives of Heredity Introduction Career Focus Introduction to Prokaryotic and Eukaryotic Cell Cell Division An Overview of the Cell Cycle The Mechanics of Cell Division Mitosis in Detail Meiosis Characteristics and Structure of DNA and Chromosomes—DNA Packaging and Chromosome Condensation Chromosomes and Sex Determination Overview of Chromosome Morphology Principles of Genetics: Mendelian Principles Mendel’s Experimental Organism: The Pea Plant Mendel’s Experiment: Monohybrid and Dihybrid Crosses Pedigree Patterns of Inheritance in Humans Multiple Alleles and Blood Groups The ABO Blood Group Function of IA, IB and I Alleles of The ABO Gene Other Genetic Systems That Exhibit Multiple Allelism Review Question Maternal, Prenatal and Genetic Influences on Development of Defects and Diseases Infections During Pregnancy Consanguinity Atopy Consanguineous Marriage and Risk of Inheriting Genetic Disorder Prenatal Nutrition Maternal Nutritional Status Food Allergies Aneuploidies and Advanced Maternal Age Autosomal Aneuploidies Sex Chromosome Aneuploidies Maternal Drug Therapy Prenatal Genetic Testing and Diagnosis Indications for Prenatal Diagnosis (PND) Methods of Prenatal Diagnosis Principles of Screening Tests Non-invasive Testing Invasive Testing Effect of Drugs, Chemicals and Radiation Infertility Factors Affecting Fertility Causes of Subfertility—Male and Female Subfertility Male Subfertility Female Subfertility Assisted Reproductive Techniques Spontaneous Abortion Pathophysiology Mechanism of Abortion Incidence Clinical Types of Abortion Risk of Recurrent Pregnancy Loss Factors Involved in Recurrent Early Pregnancy Loss Genetic Factors Non-genetic Factors Miscellaneous Factors Indian Scenario Neural Tube Defects Screening of NTD with Maternal Serum Alpha-Fetoprotein (AFP) Ultrasound Evaluation of NTDs Prevention of NTD Genetic Susceptibility for NTD and Folic Acid Intake Fortification During Pregnancy Down Syndrome (Trisomy 21) Genetics of Down Syndrome Advanced Maternal Age in Down Syndrome Characteristic Features/Phenotype of Down Syndrome Medical Conditions Associated with Down Syndrome Down Syndrome Management Down Syndrome Diagnosis Review Questions Screening Methods for Genetic Defects and Diseases in Neonates and Children Newborn Screening Heterozygote Screening Presymptomatic Testing Congenital Abnormalities (Birth Defects) and Dysmorphology Clinical Dysmorphology—Classification of Foetal and Birth Defects Diagnostic Approach to the Dysmorphic Foetus Teratology Basic Principles of Teratology Developmental Milestones Review Questions Genetic Disorders in Adolescents and Adults Cancer as a Genetic Disease DNA Repair Genes Chromosome Mutations and Cancer The Molecular Genetics of Colorectal Cancer Inborn Errors of Metabolism Classification of Inherited Metabolic Diseases Enzyme Defects (Aminoacidopathies) Defects in Purine Metabolism (Lesch Nyhan Syndrome) Lysosomal Storage Diseases Genetic Haemochromatosis (GH) Huntington’s Disease Deregulation in Protein Pathways NRSE Mediated Pathway Therapeutic Modalities for Management of HD Mental Health Suggested Reading Review Questions Role of Nurse in Genetic Services and Counselling Types of Gene Therapy Classification Based on Type of Therapy Classification Based on the Method of Therapy Vectors Used Non-Viral Vector Systems Special Gene Therapy Strategies Impact of Genetic Condition on Families Genetic Counselling Legal and Ethical Issues Ethical Issues in Prenatal Diagnosis (Adapted from WHO Guidelines on Ethical Issues in Medical Genetics) Ethical Issues in Genetic Testing of Children Privacy of Genetic Information and Its Misuse Role of a Nurse Review Questions Annexure 1 Annexure 2: Rare Genetic Disorders Case Studies Case Study 1 Case Study 2 Case Study 3 Case Study 4 Case Study 5 Case Study 6 Case Study 7 Case Study 8 Case Study 9 Case Study 10 Index Illustrations Copyright

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deepa p genetics nurses 2ed 2024