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hughes j clinical chemistry made easy 2008

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Textbook in PDF format This title is directed primarily towards health care professionals outside of the United States. It presents the important aspects of clinical chemistry in the "Made Easy" format for the senior clinical medical student or junior doctor on the ward. The book explains the rationale underlying the most common clinical chemistry tests to request and gives guidance as to what action is required on receipt of abnormal results. The text includes brief background to the underlying physiological processes involved, important differential diagnoses and further steps required in the clinical setting. The ultimate aim is to make the reader think carefully as to what clinical chemistry tests are required in different contexts and to ensure that they are equipped to deal responsibly with the result. This will result in improved clinical practice. Made Easy format. Aimed at the clinician using clinical chemistry tests on the ward (and not the laboratory-based scientist). Will allow rationale choice of correct test. Gives guidance on how to react to abnormal results Foreword Preface Sodium and water balance Introduction Distribution Control of sodium balance Control of water balance When should I check sodium level? What do I do with the result? Hyponatraemia (serum Na 145 mmol/L) Assessment of polyuria Disorders of potassium balance Distribution Potassium excretion When should I check potassium level? Patients with cardiac disease Figure 2.2 Renal excretion of potassium. Potassium secretion is controlled in thecortical collecting duct (CCD). Sodium reabsorption in this segment produces anegative voltage gradient, promoting K secretion under the actions of aldosterone.Aldo-R, aldosterone receptor. Patients receiving drugs that may affect serumpotassium level Patients with diabetes mellitus Patients with major fluid and electrolyte fluxes Patients with renal impairment Patients with weakness of unknown aetiology What do I do with the result? Hypokalaemia Assessment of renal function and urinary protein excretion Metabolic acid–base disorders Arterial blood gas analysis Calcium, phosphate and magnesium metabolism Liver function tests Lipid disorders Markers of cardiac and muscle injury and disease Immunological investigations Index

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hughes j clinical chemistry made easy 2008

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