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Details for:
Khan R. SERS-Based Advanced Diagnostics for Infectious Diseases 2023
khan r sers based advanced diagnostics infectious diseases 2023
Type:
E-books
Files:
1
Size:
14.4 MB
Uploaded On:
June 4, 2023, 3:04 p.m.
Added By:
andryold1
Seeders:
1
Leechers:
5
Info Hash:
9398B9A7DF254317625CB092C093F8CEEC259DA0
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Textbook in PDF format Raman spectroscopy enables the identification of molecular vibrations giving characteristic specific signals of each molecule. However, it has some limitations of its own such as that low-density scattering signals are very weak and they get capped with other noise signals. Surface enhanced Raman spectroscopy (SERS) is a powerful technique which has gained much attention in the research community due to its several advantages. Among emerging novel detection techniques, SERS has come out as a robust analytical tool for analysis of single-molecule-level sensitivity and capacity of quantitative detection. In the SERS sensing technique, amplified inelastic light scatters from the molecules after being absorbed on the surface of metals. The frequency modulation of excitation light and localized surface plas monic resonance (LSPR) of the metallic nanomaterial could enhance the scattering signal by a thousand times. The potential of SERS significantly increased after the discovery of its detection of microorganisms. The future clinical applications paved the way in healthcare for the rapid detection of pathogens, especially viruses. Infectious diseases, which are caused by pathogens such as bacteria and viruses, are responsible for millions of deaths worldwide. Respiratory infectious diseases, such as influenza, tuberculosis, and pneumonia, lead to 5 million deaths every year. Recently, the advent of coronavirus disease has resulted in an ongoing global COVID-19 pandemic. Driven by the growing demand for healthcare and point-of care test applications, next-generation diagnostic tools of diseases require sensing platforms that enable rapid, quantitative readout of analytes with excellent specificity and sensitivity. SERS-based detection methods have shown promise in overcoming the low sensitivity and multiplex detection problems inherent to conventional detection methods like RT-PCR, ELISA, LFIA, CRISPR, LAMP, etc. SERS technology has appeared as one of the most reliable emerging technol ogies among the various other biosensors and gained much attention due to its extraordinary properties like ultra-sensistivity and specificity, and its utilization in different fields of science like biomedical, energy conversion, physics, chemical sensing, biosensing, material science, photocatalysis, etc. Preface 1 Fundamentals of surface-enhanced Raman spectroscopy in diagnostics 2 Overview of infectious diseases and its diagnostic techniques 3 Historical review of SERS in biomedical applications: infectious diseases 4 Use of nanotechnology in SERS-based diagnostics 5 Significance, design, and synthesis methods of SERS tags/probes 6 SERS integrated detection techniques for clinical samples: overcoming challenges 7 SERS based conventional diagnostics for the diagnosis of SARS-CoV-2 8 SERS-based lateral flow immunoassay for viral infections 9 SERS-based microfluidics for real sample detection 10 IoMT-based SERS detection as advanced diagnostics 11 Optimization of SERS set-ups for high-efficiency and rapid detection of infectious diseases 12 Future potential of SERS-based advanced diagnosis in real-life conditions
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Khan R. SERS-Based Advanced Diagnostics for Infectious Diseases 2023.pdf
14.4 MB
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