PirateBay Download | nesterova disease pathways atlas human disease 2020

nesterova disease pathways atlas human disease 2020

Type:: E-books
Files:: 2
Size:: 157.8 MB
Uploaded On:: June 19, 2022, 4:34 p.m.
Added By:: andryold1
Seeders:: 1
Leechers:: 0
Info Hash:: CFE6C0022E2822A9D982D665FCFD40E6F6997F5D

Textbook in PDF and DJVU formats Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Key Features Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources. Readership Endocrinologists, neurologists, cardiologists, immunologists, molecular biologists, geneticists, biochemists, students, and researchers who require information to understand cellular and molecular mechanisms of human diseases Disease Pathways: An Atlas of Human Disease Signaling Pathways Copyright Contributors Foreword: The future of medical discovery Preface Intended audience Guide and legend Introduction Terminology of cellular systems Signal reception Signal transduction inside the cell Cell response Major signaling pathways Diverse definitions and concepts of systems biology Pathways as objects for analysis in systems biology Pathways ontology and disease pathways Reconstruction of disease pathways described in the book References Human disease pathways Infectious diseases Human immunodeficiency virus (HIV) and Łacquired immunodeficiency syndrome (AIDS) Outcome effects Transport to the nucleus and viral integration Viral reproduction Outcome effects Signaling Low level of viral production Postintegration latency References Human T-cell leukemia virus infection and leukemia progression Signaling References Human papillomavirus infection and cancer Signaling References Diseases of the blood Anemia of chronic disease (inflammatory anemia) Signaling References Hemophilia Coagulation cascade Feedback relations between coagulation and fibrinolysis References Endocrine, nutritional, and metabolic diseases Diabetes mellitus type I Signaling Inducing signals Signaling References Type diabetes mellitus Signaling Insulin processing and storage Insulin secretion Signaling Proliferation Neogenesis/dedifferentiation Recovery Outcome effects Inflammation-related insulin resistance FFA-related insulin resistance References Diabetic neuropathy Signaling References Hypothyroidism Thyrotropin-releasing hormone Thyroid stimulating hormone TSHR signaling and thyroid follicle cells Hashimoto’s thyroiditis General pathways of thyroid hormone signaling Cell-specific effects of thyroid hormone action References Alpha- antitrypsin deficiency Signaling References Cystic fibrosis Signaling Outputs Mucus production Oxidative stress References Diseases of the nervous system Alzheimer’s disease Signaling References Amyotrophic lateral sclerosis Signaling References Familial hemiplegic migraine (FHM) NO and PGH synthesis in neuronal tissue NO-mediated vasodilation Outcome effects Signaling References Diseases of the eye Glaucoma Signaling References Age-related macular degeneration Signaling References Cataract Signaling References Diseases of the ear Hearing loss Signaling References Otitis media Signaling References Diseases of the circulatory system Atherosclerosis description Signaling The first mechanism is NO and ROS production The third mechanism is ECM remodeling Signaling References Hypertension Signaling References Pulmonary arterial hypertension Signaling References Hypertrophic cardiomyopathy Signaling References Arrhythmogenic right ventricular dysplasia (ARVD) Signaling References Diseases of the respiratory system Asthma Key cellular contributors and processes Outputs Antigen-presenting cells in asthma IgE antibodies production Outcome effects Eosinophil migration and activation Eosinophil apoptosis Neutrophil chemotaxis and activation Outcome effects Mucins release Regulation of airway surface liquid thickness Airway smooth muscle cell contraction ASM proliferation and airway tissue remodeling References Chronic obstructive pulmonary disease Key cellular contributors and processes Signaling References Diseases of the digestive system Crohn’s disease Incoming signals Signaling References Ulcerative colitis Outcome effects Cell-to-cell junctions Short-chain fatty acids Signaling Polymorphisms associated with inflammatory bowel diseases References Celiac disease Signaling References Nonalcoholic fatty liver disease Signaling References Diseases of the skin and subcutaneous tissue Acne vulgaris Signaling References Atopic dermatitis Signaling Outcome effects Signaling References Psoriasis Signaling References Ichthyosis Signaling References Diseases of the musculoskeletal system Osteoarthritis Signaling References Osteoporosis (type I) Signaling References Osteopetrosis Signaling References Diseases of the genitourinary system Pyelonephritis Signaling References Glomerulonephritis Signaling References Polycystic kidney disease Signaling References Polycystic ovary syndrome Signaling References Endometriosis Signaling References Pathway analysis perspectives/advantages Applications of disease pathways in biology and medicine Pathway analysis for personalized medicine Bioinformatics foundation for patient data analysis Gene grouping techniques Pathway analysis as a part of functional enrichment analysis Pathway topology–based enrichment analysis Network-based enrichment analysis Pathway and network analysis output interpretation In silico modeling in biomedicine Pathway collections and network databases Software and tools Conclusion References Glossary and index Links Index Back Cover

Get This Torrent

Nesterova A. Disease Pathways. An Atlas of Human Disease Signaling Pathways 2020.djvu 12.8 MB
Nesterova A. Disease Pathways. An Atlas of Human Disease...2020.pdf 145.0 MB

Details for: Nesterova A. Disease Pathways. An Atlas of Human Disease...2020

nesterova disease pathways atlas human disease 2020