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filardo g orthobiologics injectable therapies 2022

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Textbook in PDF format This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts. Injectable Orthobiologics: Formulations and Rationale The Stem and Progenitor Cell Paradigms and Engineering Principles Guiding the Clinical Use of Cells or Cell-Derived Products for Regenerative Medicine Bone Marrow as a Source of Cells for Musculoskeletal Cellular Therapies Adipose-Derived Stem/Stromal Cells, Stromal Vascular Fraction, and Microfragmented Adipose Tissue Injections of Synovial Mesenchymal Stromal Cells Placenta, Umbilical Cord, and Umbilical Cord Blood-Derived Cultured Stromal Cells Injectable Allogenic Mesenchymal Stromal Cells: Advantages, Disadvantages, and Challenges Injection of Steroid Hormones Intra-articular Hyaluronic Acid Injections Cytokines, Chemokines, Alpha-2-Macroglobulin, Growth Factors Platelet-Rich Plasma: Processing and Composition Placental Tissue Extracts Secretome, Extracellular Vesicles, Exosomes Injectable Orthobiologics: Methods and Results Based on Anatomy and Pathology Rotator Cuff Tendinopathy: Cell Therapy Rotator Cuff Tendinopathy: Biologics Orthobiologics for the Treatment of Tennis Elbow Patellar Tendinopathy: Cell Therapy Patellar Tendinopathy: Biologics Orthobiologics for the Treatment of Achilles Tendinopathy Orthobiologics for the Treatment of Plantar Fasciitis Ligament Lesions: Cell Therapy Ligament Lesions: Biologics Meniscal Lesions: Cell Therapy Meniscal Lesions: Biologics Orthobiologics for the Treatment of Muscle Lesions Cartilage Lesions and Osteoarthritis: Cell Therapy Cartilage Lesions and Osteoarthritis of the Knee: Biologics Cartilage Lesions and Osteoarthritis of the Hip and Ankle: Orthobiologics Injectable Orthobiologics for the Treatment of Subchondral Insufficiency Fractures of the Knee (SIFK) and Related Pathogenic Processes Injections: Orthobiologics and the Power of Placebo Future Directions Pluripotent Stem Cells: Embryonic/Fetal Stem Cells and Induced Pluripotent Stem Cells Gene Therapy In Situ Targeting of Stem and Progenitor Cells in Native Tissues

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Filardo G. Orthobiologics. Injectable Therapies...2022.pdf 11.8 MB

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filardo g orthobiologics injectable therapies 2022