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obulesu m plant extracts neurodegenerative diseases 2022

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Textbook in PDF format Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease. Front Cover Plant Extracts in Neurodegenerative Diseases Copyright Dedication About the author Acknowledgments Effect of plant extracts against Alzheimer’s disease Introduction Pathology Plant extracts Diet Polyphenols Flavonoids Genistein Icariside Onjisaponin Asarones Liquiritin Tanshinone IIA and cryptotanshinone Ginsenoside Rg1 n -Butylidenephthalide Green nanotechnology Conclusions and future perspectives References Potential plant extracts in the treatment of Parkinson’s disease Introduction Pathology α -Synuclein Plant extracts Pharmacological chaperones combat Parkinson’s disease Phytochemicals Baicalein Curcumin Nanotechnology Scutellaria pinnatifida ( S. pinnatifida) Hypericum perforatum Mentha × piperita (peppermint) Cyanobacteria spirulina Omega-3 fatty acids Conclusions and future perspectives References Panoply of plant extracts in the treatment of prion diseases Introduction Pathology Plants and prions Metal dyshomeostasis Plants Polyphenols Resveratrol Curcumin Polyphenolic metal chelators Mediterranean diet Lichens Conclusions and future perspectives References Efficacy of plant extracts against Friedreich’s ataxia Introduction Pathology Frataxin Iron accumulation Iron dyshomeostasis in Friedreich’s ataxia Plant extracts Coenzyme Q10 and idebenone Nuclear factor erythroid 2-related factor Resveratrol Antioxidants Conclusions and future perspectives References Further reading Plant extracts ameliorate Huntington’s disease symptoms Introduction Pathology Free radicals Antioxidants Oxidative stress in Huntington’s disease Plant extracts Clinical trials Cleistocalyx nervosum var. paniala Guarana Protective efficacy of guarana against neurodegenerative diseases Conclusions and future perspectives References Phytochemicals and their potential protective effects against spinocerebellar ataxia Introduction Pathology Dendrite Plant extracts Ubiquitin-proteasome system and mechanism of action Antioxidant activity Ginkgo biloba Bacopa monnieri Chionanthus retusus Lindl. et Paxton ( C. retusus) Azadiradione Conclusions and future perspectives References Multifarious plant compounds and their protective efficacy in the treatment of spinal muscular atrophy Introduction Pathology Nusinersen therapy Plant extracts Kiwi fruit RNA-targeted therapy Conclusions and future perspectives References Improvement of amyotrophic lateral sclerosis symptoms using plant extracts Introduction Pathology DNA damage Plant extracts Clinical trials Mecasin Ashwagandha Withaferin A Drawbacks Polyphenols Resveratrol Curcumin Conclusions and future perspectives References Further reading Neuroprotective role of curcumin in amyotrophic lateral sclerosis Introduction Pathology Oxidative stress Therapy Curcumin Dimethoxy curcumin Curcumin against TDP-43 Use of adjuvants Nanotechnology Nanocurcumin in the treatment of ALS Conclusions and future perspectives References Index Back Cover

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obulesu m plant extracts neurodegenerative diseases 2022