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maurya p nanobioanalytical approaches medical diagnost 2022

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Textbook in PDF format Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system – offering targeted and detailed diagnostic results in a range of biomedical applications. This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing. Contributors Preface Prospects of fluidic force microscopy and related biosensors for medical applications Atomic force microscopy Cell biology with AFM Fluidic force microscopy Single-cell force spectroscopy by FluidFM Bacterial adhesion measured by FluidFM Eukaryotic cell adhesion Additional fluidic force microscopy functions Measurements by computer-controlled micropipette Label-free biosensors for cell adhesion analysis Summary Acknowledgments References Point of care diagnostics for cancer Recent trends and challenges Introduction Role of biomarkers in the detection of cancer Types of biomarkers for cancer detection Protein-based biomarkers Nucleic acid-based biomarkers Cancer cell-based biomarkers Metabolites-based biomarkers Exosomes Toward early detection of cancer Point-of-care diagnostics for cancer Introduction Types of point of care devices in cancer Imaging tools-based point of care diagnostics Ultrasound-based POC cancer diagnostics Optical imaging Nuclear medicine imaging Biosensors-based point-of-care diagnostic tools Electrochemical biosensors Optical biosensors Piezoelectric biosensors Conclusion and future perspectives Acknowledgments References Bioelectrochemical methods in biomolecular analysis Introduction Types of bioelectrochemical methods for bimolecular analysis Working mechanism Voltammetric/amperometric biosensors Potentiometric biosensors Impedimetric biosensors Bioelectrochemical system based biosensor Application of bioelectrochemical system based biosensor Detection of hexavalent chromium Detection of toxic compounds Detection of acetaldehyde Detection of fumarate Determination of water quality Detection of volatile fatty acids Detection of dissolved oxygen Detection of chemical oxygen demand Detection of biological oxygen demand Bioelectrochemical methods for cell analysis Scanning electrochemical microscopy (SECM) method Detection of assimilable organic carbon Detection of acetate Bioelectrochemical methods for cell analysis Bioelectrochemical methods for cell culture fabrication and cell stimulation Prospective and future trends References Electrochemical nano-aptasensor as potential diagnostic device for thrombin Introduction Aptasensor Aptamer Selection of aptamer Immobilization methods of aptamer Incorporation of nanomaterials Detection systems in aptasensing Optical detection Electrochemical detection Thrombin Significance of thrombin Conventional detection methods of thrombin Thrombin-binding aptamers Application of electrochemical aptasensors in thrombin detection Conclusions and future outlook Conflict of interest Acknowledgments References Antibiotics and analytical methods used for their determination Introduction Antibacterial drugs and the extent of their use Classic methods of antibiotic determination Biosensor approaches to antibiotic determination Electrochemical biosensors Immunosensors Aptasensors Molecularly imprinted polymer sensors Acoustic biosensors Microbial sensory systems for antibiotic detection Optical biosensors Conclusion Acknowledgments Conflict of interest References Integration of microfluidics with biosensing technology for noncommunicable disease diagnosis Introduction Biosensor technology Classification of biosensors Enzyme-based biosensors Antibody-based biosensors Aptamers-based biosensors Microfluidics technology Fluid dynamics in microfluidics Fluid viscosity Momentum and Navier Stokes equation Microfluidics-based biosensors Applications of microfluidic-based biosensor Cancer diagnostics Cardiovascular disease detection Cholesterol monitoring Early assessment of diabetes mellitus Communication technology Combining sensors with communication infrastructure WSN in monitoring non-communicable disease Microfluidics-based biosensor and WSN Adoption of microfluidics biosensor in wearable technology Conclusion References Role and implication of nanomaterials in clinical diagnostics Introduction Nanomaterials in bioimaging based diagnostics Magnetic resonance imaging Positron emission tomography scan Ultrasound imaging Computed tomography Photoacoustic imaging Nanodevices Nanowires-based biosensors Nanoporous silica chips Nanofluidic devices Devices using nanocantilevers Nano-biosensors Requirement of nano-biosensors in clinical diagnosis Types of nano-biosensors Use of electrochemical immuno-nanosensors Nanomaterial-based optical sensors Photoluminescence-based optical nano-biosensors Use of nanoparticles for developing aptasensors Lateral flow assay Safety concerns and limitations of using nanoparticle Conclusion and future prospects Acknowledgments References Nano-materials in biochemical analysis Introduction Classification of nanoparticles Metallic nanoparticles Non-metallic nanoparticles Biodegradable nanoparticles Synthesis of nanoparticles Wet-chemical processes Physical methods of synthesis Gas-phase preparation Functionalization of nanomaterials for biochemical applications Biochemical applications of nanoparticles Detection of oxidative stress biomarkers Lipid-based biomarkers detection Hydrogen peroxide detection Superoxide anion detection Hydroxyl radical detection Reduced glutathione detection -Hydroxy--deoxyguanosine detection C-reactive protein detection Enzyme-like activity Nanomaterials exhibiting superoxide dismutase-like activity Nanomaterials exhibiting peroxidase-like activity Nanomaterials exhibiting oxidase-like activity Nanomaterials exhibiting catalase-like activity Conclusion and future prospects References Lignocellulose-based nanomaterials for diagnostic and therapeutic applications Introduction Lignocellulose and its composition Nanoparticles from lignocellulose Preparation Lignin based nanomaterials Cellulose based nanomaterials Techniques used for preparing nano-cellulose High-pressure homogenization Microfluidization Cryocrushing Grinding High intensity ultrasonication (HIUS) Steam explosion Biomedical applications of LCB nanomaterials Conclusion and future prospects References Bioanalytical approaches in detection of free radicals and RONS Introduction Overview of ROS detection methods Conventional ex vivo bioanalytical methods Colorimetric methods Fluorescence spectrometry-based methods Immunoblotting approach for indirect ROS effects Conventional in vivo methods Microscopy based direct visualization of radical and RNOS Flow cytometry based semi-quantitative analysis Live imaging methods Advance methods for radical/RNOS detection ESR-based methods NMR-based methods Conclusion References Nano-biosensors for biochemical analysis Introduction Biosensors Types AuNP-based biosensors Carbon nanotube based biosensors Quantum dots based biosensors Nanoparticles in analytical biochemistry Glucose biosensor Choline nanosensors Lactate biosensor Triglyceride nanosensors Ochratoxin A detection Nanoparticles in bioassays C-reactive protein Applications Conclusion and future perspectives Acknowledgments References Nanobiomaterials in biomedicine Designing approaches and critical concepts Introduction Nanomaterials and it's applications in nanomedicine Fundamentals of nanotechnology based techniques in designing of drug Nanoparticles used in drug delivery system Polymeric micelles Polymeric nanoparticles Polymeric drug conjugates Dendrimers Nanocrystals Liposomes Nanoparticles based on solid lipids Inorganic nanoparticles Silica materials Conclusion References Erythrocytes model for oxidative stress analysis Oxidative stress Stress Cold stress Physical exercise and stress Chronic stress Nutritional stress Hypoxic stress Oxidative stress and diseases Oxidative stress and autoimmune diseases Oxidative stress and rheumatoid arthritis Rheumatoid arthritis (RA) Oxidative stress measurement in RA Oxidative stress and erythrocytes Conclusion Acknowledgment Authors contributions References Lipid film based biosensors A protection tool for the public health Introduction Construction of lipid film based nanosensors Metal supported lipid membranes Stabilized lipid films formed on a glass fiber filter Polymer-supported bilayer lipid membranes Polymer lipid films supported on graphene and ZnO microelectrodes Fabrication of biosensors with nanoporous lipid membranes Applications of lipid film based biosensors in clinical analysis for the protection of public health Conclusion References Index Back Cover

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