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Details for:
Cromm P. Inducing Targeted Protein Degradation...2023
cromm p inducing targeted protein degradation 2023
Type:
E-books
Files:
1
Size:
33.9 MB
Uploaded On:
Jan. 1, 2023, 7:56 p.m.
Added By:
andryold1
Seeders:
11
Leechers:
0
Info Hash:
B388741E18F4D024B2234AFD0511FB0F6A465E75
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Textbook in PDF format Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches. Targeted Protein Degradation – The Story So Far Cellular Principles of Targeted Protein Degradation E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation Computational Modeling of PROTAC Ternary Complexes and Linker Design Molecular Glue Degraders: From Serendipity to Hunting and Design Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases Insights and Future Perspectives of Covalent Protein Degraders Extending the Degradation Toolkit – mRNA Targeting as an Alternative Means to Affect Protein Levels The Future of Heterobifunctional Compounds: PROTACs and Beyond Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery Taming the Beast: How to Optimize DMPK–PD Properties of Oral Degraders PROTAC Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates
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Cromm P. Inducing Targeted Protein Degradation...2023.pdf
33.9 MB
