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Details for:
Grieve A. Hybrid Frequentist-Bayesian Power...in Planning Clinical Trials 2022
grieve hybrid frequentist bayesian power planning clinical trials 2022
Type:
E-books
Files:
1
Size:
6.2 MB
Uploaded On:
Jan. 1, 2023, 8:06 p.m.
Added By:
andryold1
Seeders:
7
Leechers:
0
Info Hash:
9806577AE9DEB4F08BE98E2FE8BC6354553E1819
Get This Torrent
Textbook in PDF format Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials provides a practical introduction to unconditional approaches to planning randomised clinical trials, particularly aimed at drug development in the pharmaceutical industry. This book is aimed at providing guidance to practitioners in using average power, assurance and related concepts. This book brings together recent research and sets them in a consistent framework and provides a fresh insight into how such methods can be used. Features A focuson normal theory linking average power, expected power, predictive power, assurance, conditional Bayesian power and Bayesian power.Extensions of the concepts to binomial, and time-to-event outcomes and non-inferiority trialsAn investigation into the upper bound on average power, assurance and Bayesian power based on the prior probability of a positive treatment effectApplication of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program, or to the successful outcome of an interim analysisPrior distribution of power and sample sizeExtension of the basic approach to proof-of-concept trials with dual success criteriaInvestigation of the connection betweenconditional and predictive power at an interim analysis and power and assuranceIntroduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect, and an unconditional version
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Grieve A. Hybrid Frequentist-Bayesian Power...in Planning Clinical Trials 2022.pdf
6.2 MB
